InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGA2B

Summary

InnateDB Gene

IDBG-53910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA2B

Gene Name

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Synonyms

BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93

Species

Homo sapiens

Ensembl Gene

ENSG00000005961

Encoded Proteins

IDBP-53912

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

IDBP-760169

IDBP-764854

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44372180-44389505

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000262407	ENSP00000262407
ENST00000592075
ENST00000592944
ENST00000587295	ENSP00000467269
ENST00000592253
ENST00000592226
ENST00000589645
ENST00000592462
ENST00000588098	ENSP00000465534
ENST00000591990

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0050840	extracellular matrix binding
GO:0070051	fibrinogen binding

Biological Process

GO:0002576	platelet degranulation
GO:0002687	positive regulation of leukocyte migration
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0070527	platelet aggregation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031092	platelet alpha granule membrane
GO:0072562	blood microparticle