InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADH5

Summary

InnateDB Gene

IDBG-640968.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADH5

Gene Name

Alcohol dehydrogenase class-3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016007

Encoded Proteins

IDBP-693272

Alcohol dehydrogenase class-3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197894:
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:26901379-26916216

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021304

ENSBTAP00000021304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0005504	fatty acid binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0018467	formaldehyde dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0003016	respiratory system process
GO:0006069	ethanol oxidation
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0032496	response to lipopolysaccharide
GO:0045777	positive regulation of blood pressure
GO:0046294	formaldehyde catabolic process
GO:0051409	response to nitrosative stress
GO:0051775	response to redox state
GO:0055114	oxidation-reduction process