InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ADH5

Summary

InnateDB Protein

IDBP-693272.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADH5

Protein Name

Alcohol dehydrogenase class-3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021304

InnateDB Gene

IDBG-640968 (ADH5)

Protein Structure

UniProt Annotation

Function

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0005504	fatty acid binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0018467	formaldehyde dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0003016	respiratory system process
GO:0006069	ethanol oxidation
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0032496	response to lipopolysaccharide
GO:0045777	positive regulation of blood pressure
GO:0046294	formaldehyde catabolic process
GO:0051409	response to nitrosative stress
GO:0051775	response to redox state
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR014183 Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZC42