Version 5.4
Bos taurus Gene: PTPRE
Summary
InnateDB Gene IDBG-641003.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRE
Gene Name receptor-type tyrosine-protein phosphatase epsilon
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002435
Encoded Proteins
IDBP-693365
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132334:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:47801368-47842727
Strand Forward strand
Band
Transcripts
ENSBTAT00000003163 ENSBTAP00000003163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311 dephosphorylation
GO:0033003 regulation of mast cell activation
GO:0046627 negative regulation of insulin receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000132334
View Gene Order
ENSMUSG00000041836
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL F1MP45 Q148I7
UniProt Splice Variant
Entrez Gene 505285
UniGene Bt.23655
RefSeq NM_001205531 XM_005225844
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118291 DAAA02059581 DAAA02059582
GenPept AAI18292
RNA Seq Atlas 505285

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca