InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BMPR1B

Summary

InnateDB Gene

IDBG-641011.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMPR1B

Gene Name

bone morphogenetic protein receptor type-1B

Synonyms

ALK6; BMP15; BMPR-IB; BMPRIB

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002081

Encoded Proteins

IDBP-693331

bone morphogenetic protein receptor type-1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138696:
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:30798831-30850160

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002690

ENSBTAP00000002690

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046332	SMAD binding

Biological Process

GO:0001501	skeletal system development
GO:0001502	cartilage condensation
GO:0001550	ovarian cumulus expansion
GO:0001654	eye development
GO:0002062	chondrocyte differentiation
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009953	dorsal/ventral pattern formation
GO:0016310	phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0031290	retinal ganglion cell axon guidance
GO:0035108	limb morphogenesis
GO:0042698	ovulation cycle
GO:0043010	camera-type eye development
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0060041	retina development in camera-type eye
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors