Version 5.4
Mus musculus Gene: Bmpr1b
Summary
InnateDB Gene IDBG-196928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bmpr1b
Gene Name bone morphogenetic protein receptor, type 1B
Synonyms Acvrlk6; AI385617; ALK-6; Alk6; AV355320; BMPR-1B; BMPR-IB; CFK-43a; SKR6
Species Mus musculus
Ensembl Gene ENSMUSG00000052430
Encoded Proteins
IDBP-196930
bone morphogenetic protein receptor, type 1B
IDBP-196932
bone morphogenetic protein receptor, type 1B
IDBP-269208
bone morphogenetic protein receptor, type 1B
IDBP-269210
bone morphogenetic protein receptor, type 1B
IDBP-533773
bone morphogenetic protein receptor, type 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:141837136-142169425
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000029948 ENSMUSP00000029948
ENSMUST00000098568 ENSMUSP00000096167
ENSMUST00000106232 ENSMUSP00000101839
ENSMUST00000106230 ENSMUSP00000101837
ENSMUST00000131273 ENSMUSP00000117478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046332 SMAD binding
GO:0046872 metal ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001550 ovarian cumulus expansion
GO:0001654 eye development
GO:0002062 chondrocyte differentiation
GO:0006468 protein phosphorylation
GO:0006703 estrogen biosynthetic process
GO:0006954 inflammatory response
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009953 dorsal/ventral pattern formation
GO:0023014 signal transduction by phosphorylation
GO:0030154 cell differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031290 retinal ganglion cell axon guidance
GO:0035108 limb morphogenesis
GO:0042698 ovulation cycle
GO:0043010 camera-type eye development
GO:0045597 positive regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0060041 retina development in camera-type eye
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138696
View Gene Order
ENSBTAG00000002081
Not yet available
Pathways
NETPATH
REACTOME
REACT_220505
Signaling by BMP pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04350
TGF-beta signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12034
Signaling by BMP pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.39089
RefSeq NM_001277216 NM_001277217 NM_001277218 NM_001277220 NM_007560 XM_006500939 XM_006500940 XM_006500941 XM_006500942 XM_006500943 XM_006500944 XM_006500945
OMIM
CCDS CCDS17874
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca