InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLCD3

Summary

InnateDB Gene

IDBG-641066.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCD3

Gene Name

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006052

Encoded Proteins

IDBP-693389

phospholipase C, delta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161714:
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45411512-45432420

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000034821

ENSBTAP00000034705

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0060716	labyrinthine layer blood vessel development