Version 5.4
Mus musculus Gene: Plcd3
Summary
InnateDB Gene IDBG-212898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plcd3
Gene Name phospholipase C, delta 3
Synonyms 2610205J15Rik; mKIAA1964
Species Mus musculus
Ensembl Gene ENSMUSG00000020937
Encoded Proteins
IDBP-212900
phospholipase C, delta 3
IDBP-539259
phospholipase C, delta 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161714:
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:103070304-103101658
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000103077 ENSMUSP00000099366
ENSMUST00000128650 ENSMUSP00000117455
ENSMUST00000124740
ENSMUST00000143012
ENSMUST00000142970
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0001525 angiogenesis
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell proliferation
GO:0060716 labyrinthine layer blood vessel development
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0032154 cleavage furrow
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161714
View Gene Order
ENSBTAG00000006052
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_152813 XM_006534308 XM_006534309 XM_006534310 XM_006534311
OMIM
CCDS CCDS25512
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca