Homo sapiens Gene: IL1RL2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-64113.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | IL1RL2 | ||||||||||||||||||
Gene Name | interleukin 1 receptor-like 2 | ||||||||||||||||||
Synonyms | IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000115598 | ||||||||||||||||||
Encoded Proteins |
interleukin 1 receptor-like 2
interleukin 1 receptor-like 2
interleukin 1 receptor-like 2
interleukin 1 receptor-like 2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
IL1RL2 binds members of the interleukin (IL)-1 family of cytokines that includes IL1F6, IL1F8 and IL1F9. Binding of these ligands to IL1RL2 plays a critical role in the interface between innate and adaptive immunity, leading to the stimulation of dendritic and T helper cell responses. (Demonstrated in murine model)
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InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Mus musculus] Il1rl2 binds members of the interleukin (IL)-1 family of cytokines that includes Il1f6, Il1f8 and Il1f9. Binding of these ligands to Il1rl2 plays a critical role in the interface between innate and adaptive immunity, leading to the stimulation of dendritic and T helper cell responses.
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Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:102186973-102240002 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q12.1 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.659863 | ||||||||||||||||||
RefSeq | NM_003854 XM_005264035 XM_005264036 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS2056 | ||||||||||||||||||
HPRD | 05150 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||