Homo sapiens Gene: GH2 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-64119.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | GH2 | ||||||||||||
Gene Name | growth hormone 2 | ||||||||||||
Synonyms | GH-V; GHL; GHV; hGH-V | ||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Gene | ENSG00000136487 | ||||||||||||
Encoded Proteins |
growth hormone 2
growth hormone 2
growth hormone 2
growth hormone 2
growth hormone 2
growth hormone 2
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 17:63880215-63881935 | ||||||||||||
Strand | Reverse strand | ||||||||||||
Band | q23.3 | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
No orthologs found for this gene | |||||||||||||
Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Growth hormone receptor signaling pathway
Prolactin receptor signaling pathway
Nuclear signaling by ERBB4 pathway
Signaling by ERBB4 pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Immune System pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | Hs.406754 | ||||||||||||
RefSeq | NM_002059 NM_022556 NM_022557 NM_022558 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | CCDS11647 CCDS11648 CCDS45757 CCDS45758 | ||||||||||||
HPRD | 00750 | ||||||||||||
IMGT | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||