Version 5.4
Homo sapiens Gene: GH2
Summary
InnateDB Gene IDBG-64119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GH2
Gene Name growth hormone 2
Synonyms GH-V; GHL; GHV; hGH-V
Species Homo sapiens
Ensembl Gene ENSG00000136487
Encoded Proteins
IDBP-64123
growth hormone 2
IDBP-383115
growth hormone 2
IDBP-383117
growth hormone 2
IDBP-383118
growth hormone 2
IDBP-813453
growth hormone 2
IDBP-813454
growth hormone 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63880215-63881935
Strand Reverse strand
Band q23.3
Transcripts
ENST00000332800 ENSP00000333157
ENST00000456543 ENSP00000394122
ENST00000423893 ENSP00000409294
ENST00000449787 ENSP00000410618
ENST00000622506 ENSP00000481086
ENST00000617594 ENSP00000478299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.406754
RefSeq NM_002059 NM_022556 NM_022557 NM_022558
HUGO
OMIM
CCDS CCDS11647 CCDS11648 CCDS45757 CCDS45758
HPRD 00750
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca