Version 5.4
Bos taurus Gene: VAPB
Summary
InnateDB Gene IDBG-641243.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAPB
Gene Name Vesicle-associated membrane protein-associated protein B
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017424
Encoded Proteins
IDBP-693579
Vesicle-associated membrane protein-associated protein B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124164:
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:58463228-58510710
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023164 ENSBTAP00000023164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048487 beta-tubulin binding
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006986 response to unfolded protein
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0019048 modulation by virus of host morphology or physiology
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000124164
View Gene Order
ENSMUSG00000054455
View Gene Order
Pathways
NETPATH
REACTOME
REACT_204257
Sphingolipid de novo biosynthesis pathway
REACT_222556
Sphingolipid metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.112181 Bt.15679
RefSeq NM_001082423
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca