Version 5.4
Bos taurus Protein: VAPB
Summary
InnateDB Protein IDBP-693579.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAPB
Protein Name Vesicle-associated membrane protein-associated protein B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023164
InnateDB Gene IDBG-641243 (VAPB)
Protein Structure
UniProt Annotation
Function Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048487 beta-tubulin binding
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006986 response to unfolded protein
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0019048 modulation by virus of host morphology or physiology
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000535 MSP domain
IPR008962 PapD-like
IPR016763 Vesicle-associated membrane protein
PFAM PF00635
PRINTS
PIRSF PIRSF019693
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VDZ9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 326580
UniGene Bt.15679
RefSeq NP_001075892
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133497
GenPept AAI33498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca