Version 5.4
Bos taurus Gene: KLK5
Summary
InnateDB Gene IDBG-641247.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK5
Gene Name kallikrein-5 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015125
Encoded Proteins
IDBP-693588
kallikrein-related peptidase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167754:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:57391817-57401354
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027772 ENSBTAP00000027772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0097209 epidermal lamellar body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000167754
View Gene Order
ENSMUSG00000074155
View Gene Order
Cross-References
SwissProt
TrEMBL E1BGD9
UniProt Splice Variant
Entrez Gene 617418
UniGene Bt.37537
RefSeq NM_001206280 XM_005219363
HUGO HGNC:6366
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047525 DAAA02047526
GenPept
RNA Seq Atlas 617418

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca