Version 5.4
Homo sapiens Gene: KLK5
Summary
InnateDB Gene IDBG-65175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK5
Gene Name kallikrein-related peptidase 5
Synonyms KLK-L2; KLKL2; SCTE
Species Homo sapiens
Ensembl Gene ENSG00000167754
Encoded Proteins
IDBP-65177
kallikrein-related peptidase 5
IDBP-246943
kallikrein-related peptidase 5
IDBP-765417
IDBP-765218
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50943303-50953093
Strand Reverse strand
Band q13.41
Transcripts
ENST00000336334 ENSP00000337733
ENST00000391809 ENSP00000375685
ENST00000594846 ENSP00000469439
ENST00000595585
ENST00000593428 ENSP00000471966
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008544 epidermis development
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0097209 epidermal lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074155
View Gene Order
ENSBTAG00000015125
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 25818
UniGene Hs.50915
RefSeq NM_001077491 NM_001077492 NM_012427
HUGO HGNC:6366
OMIM 605643
CCDS CCDS12810
HPRD 05732
IMGT
EMBL
GenPept
RNA Seq Atlas 25818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca