InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPO11

Summary

InnateDB Gene

IDBG-641299.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPO11

Gene Name

meiotic recombination protein SPO11

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000044210

Encoded Proteins

IDBP-693645

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054796:
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5\' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:59349056-59363436

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061470

ENSBTAP00000053612

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0001541	ovarian follicle development
GO:0006259	DNA metabolic process
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0034502	protein localization to chromosome