InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPO11

Summary

InnateDB Gene

IDBG-82085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPO11

Gene Name

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

Synonyms

CT35; SPATA43; TOPVIA

Species

Homo sapiens

Ensembl Gene

ENSG00000054796

Encoded Proteins

IDBP-82087

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

IDBP-82089

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

IDBP-82091

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

IDBP-379176

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

IDBP-590577

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5\' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:57329759-57343994

Strand

Forward strand

Band

q13.31

Transcripts

ENST00000371263	ENSP00000360310
ENST00000345868	ENSP00000316034
ENST00000371260	ENSP00000360307
ENST00000418127	ENSP00000413185
ENST00000494972	ENSP00000431842

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0001541	ovarian follicle development
GO:0006259	DNA metabolic process
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0007292	female gamete generation
GO:0034502	protein localization to chromosome

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005694	chromosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005883

View Gene Order

ENSBTAG00000044210

Not yet available

Pathways

NETPATH

REACTOME

REACT_27271

Meiotic recombination pathway

REACT_115566

Cell Cycle pathway

REACT_111183

Meiosis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.159737

RefSeq

NM_012444 NM_198265 XM_005260381

HUGO

OMIM

CCDS

CCDS13456 CCDS13457

HPRD

09236

IMGT

EMBL

GenPept

RNA Seq Atlas