Version 5.4
Bos taurus Gene: TANK
Summary
InnateDB Gene IDBG-641375.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TANK
Gene Name TRAF family member-associated NF-kappa-B activator
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006654
Encoded Proteins
IDBP-693733
TRAF family member-associated NFKB activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19668221
[Homo sapiens] TANK is involved in interferon responses and is a negative regulator of pro-inflammatory cytokine production induced by TLR signalling.
PMID 21949249
[Homo sapiens] TANK plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity. (Demonstrated in mice)
PMID 21949249
[Mus musculus] Tank plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136560:
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:35247178-35342975
Strand Reverse strand
Band
Transcripts
ENSBTAT00000046172 ENSBTAP00000043495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136560
View Gene Order
ENSMUSG00000064289
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_24938
TRAF6 mediated IRF7 activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25148
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_198521
TRAF6 mediated IRF7 activation pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_225463
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6R2Z7
UniProt Splice Variant
Entrez Gene 539513
UniGene
RefSeq NM_001192264 XM_005202467 XM_005202468 XM_005202471 XM_005202472 XM_005202474
HUGO HGNC:11562
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004431 DAAA02004432
GenPept
RNA Seq Atlas 539513

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca