Bos taurus Gene: TANK
Summary
InnateDB Gene IDBG-641375.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TANK
Gene Name TRAF family member-associated NF-kappa-B activator
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006654
Encoded Proteins
TRAF family member-associated NFKB activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] TANK is involved in interferon responses and is a negative regulator of pro-inflammatory cytokine production induced by TLR signalling.
[Homo sapiens] TANK plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity. (Demonstrated in mice)
[Mus musculus] Tank plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136560:
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:35247178-35342975
Strand Reverse strand
Band
Transcripts
ENSBTAT00000046172 ENSBTAP00000043495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
MyD88-independent cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
RIG-I-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
INOH
PID BIOCARTA
Tnfr2 signaling pathway [Biocarta view]
Tnf/stress related signaling [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F6R2Z7
UniProt Splice Variant
Entrez Gene 539513
UniGene
RefSeq NM_001192264 XM_005202467 XM_005202468 XM_005202471 XM_005202472 XM_005202474
HUGO HGNC:11562
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004431 DAAA02004432
GenPept
RNA Seq Atlas 539513
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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