Mus musculus Gene: Tank
Summary
InnateDB Gene IDBG-173742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tank
Gene Name TRAF family member-associated Nf-kappa B activator
Synonyms C86182; E430026L09Rik; I-TRAF;
Species Mus musculus
Ensembl Gene ENSMUSG00000064289
Encoded Proteins
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
TRAF family member-associated Nf-kappa B activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Tank plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] TANK is involved in interferon responses and is a negative regulator of pro-inflammatory cytokine production induced by TLR signalling.
[Homo sapiens] TANK plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136560:
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:61578585-61654171
Strand Forward strand
Band C1.3
Transcripts
ENSMUST00000078074 ENSMUSP00000077219
ENSMUST00000112502 ENSMUSP00000108121
ENSMUST00000112501 ENSMUSP00000108120
ENSMUST00000112495 ENSMUSP00000108114
ENSMUST00000112494 ENSMUSP00000108113
ENSMUST00000136688
ENSMUST00000145632
ENSMUST00000139533
ENSMUST00000141544
ENSMUST00000143515
ENSMUST00000154693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
RIG-I-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Immune System pathway
MyD88-independent cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
RIG-I-like receptor signaling pathway pathway
INOH
PID BIOCARTA
Tnfr2 signaling pathway [Biocarta view]
Tnf/stress related signaling [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244393 Mm.465720
RefSeq NM_001164071 NM_001164072 NM_011529 XM_006499087 XM_006499088
OMIM
CCDS CCDS16061 CCDS50592 CCDS50593
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas