InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTGDS

Summary

InnateDB Gene

IDBG-641417.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGDS

Gene Name

Prostaglandin-H2 D-isomerase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015074

Encoded Proteins

IDBP-693779

Prostaglandin-H2 D-isomerase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107317:
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106247577-106250629

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020065

ENSBTAP00000020065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004667	prostaglandin-D synthase activity
GO:0005215	transporter activity
GO:0005501	retinoid binding
GO:0005504	fatty acid binding
GO:0016853	isomerase activity
GO:0036094	small molecule binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006693	prostaglandin metabolic process
GO:0006810	transport
GO:0045187	regulation of circadian sleep/wake cycle, sleep

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome