Version 5.4
Bos taurus Gene: TLK2
Summary
InnateDB Gene IDBG-641422.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLK2
Gene Name serine/threonine-protein kinase tousled-like 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015713
Encoded Proteins
IDBP-693792
tousled-like kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146872:
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004]
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47556655-47678473
Strand Forward strand
Band
Transcripts
ENSBTAT00000020882 ENSBTAP00000020882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001672 regulation of chromatin assembly or disassembly
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0018105 peptidyl-serine phosphorylation
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0071480 cellular response to gamma radiation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005882 intermediate filament
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146872
View Gene Order
ENSMUSG00000020694
View Gene Order
Cross-References
SwissProt
TrEMBL E1BBU6
UniProt Splice Variant
Entrez Gene 534705
UniGene Bt.53232
RefSeq NM_001192827 XM_005220902 XM_005220903 XM_005220906
HUGO HGNC:11842
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049305 DAAA02049306
GenPept
RNA Seq Atlas 534705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca