Version 5.4
Mus musculus Gene: Tlk2
Summary
InnateDB Gene IDBG-213211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tlk2
Gene Name tousled-like kinase 2 (Arabidopsis)
Synonyms 4933403M19Rik; PKU-alpha; PKUalpha; Tlk
Species Mus musculus
Ensembl Gene ENSMUSG00000020694
Encoded Proteins
IDBP-213213
tousled-like kinase 2 (Arabidopsis)
IDBP-213215
tousled-like kinase 2 (Arabidopsis)
IDBP-267718
tousled-like kinase 2 (Arabidopsis)
IDBP-267720
tousled-like kinase 2 (Arabidopsis)
IDBP-541425
tousled-like kinase 2 (Arabidopsis)
IDBP-532472
tousled-like kinase 2 (Arabidopsis)
IDBP-539295
tousled-like kinase 2 (Arabidopsis)
IDBP-532055
tousled-like kinase 2 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146872:
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004]
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:105178807-105283959
Strand Forward strand
Band E1
Transcripts
ENSMUST00000092537 ENSMUSP00000090198
ENSMUST00000015107 ENSMUSP00000015107
ENSMUST00000106941 ENSMUSP00000102554
ENSMUST00000106939 ENSMUSP00000102552
ENSMUST00000126054
ENSMUST00000145048 ENSMUSP00000118520
ENSMUST00000126175 ENSMUSP00000120944
ENSMUST00000149459 ENSMUSP00000121897
ENSMUST00000123050
ENSMUST00000152404 ENSMUSP00000123179
ENSMUST00000134419
ENSMUST00000146910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001672 regulation of chromatin assembly or disassembly
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0016568 chromatin modification
GO:0018105 peptidyl-serine phosphorylation
GO:0030154 cell differentiation
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0071480 cellular response to gamma radiation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005882 intermediate filament
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146872
View Gene Order
ENSBTAG00000015713
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.401057
RefSeq NM_001112705 NM_011903 XM_006533312 XM_006533313 XM_006533317 XM_006533319 XM_006533320 XM_006533321
OMIM
CCDS CCDS36356 CCDS48954
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca