Version 5.4
Homo sapiens Gene: DUSP15
Summary
InnateDB Gene IDBG-64150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP15
Gene Name dual specificity phosphatase 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149599
Encoded Proteins
IDBP-64152
dual specificity phosphatase 15
IDBP-64156
dual specificity phosphatase 15
IDBP-64158
dual specificity phosphatase 15
IDBP-233894
dual specificity phosphatase 15
IDBP-233896
dual specificity phosphatase 15
IDBP-370665
dual specificity phosphatase 15
IDBP-370691
dual specificity phosphatase 15
IDBP-481185
dual specificity phosphatase 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:31847637-31870747
Strand Reverse strand
Band q11.21
Transcripts
ENST00000278979 ENSP00000278979
ENST00000375966 ENSP00000365133
ENST00000339738 ENSP00000341658
ENST00000398084 ENSP00000381158
ENST00000398083 ENSP00000381157
ENST00000447647 ENSP00000397486
ENST00000428829 ENSP00000390355
ENST00000486996 ENSP00000419818
ENST00000459848
ENST00000493115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042127 regulation of cell proliferation
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042662
View Gene Order
ENSBTAG00000009005
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.585017 Hs.739467
RefSeq NM_001012644 NM_080611 NM_177991
HUGO
OMIM
CCDS CCDS13193 CCDS42862
HPRD 13252
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca