InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP15

Summary

InnateDB Protein

IDBP-64152.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP15

Protein Name

dual specificity phosphatase 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278979

InnateDB Gene

IDBG-64150 (DUSP15)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000305PubMed:15138252}.Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side.

Disease Associations

Tissue Specificity

Highly expressed in testis. {ECO:0000269PubMed:15138252}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042127	regulation of cell proliferation
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR008984 SMAD/FHA domain
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PR01908

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt