InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACE

Summary

InnateDB Gene

IDBG-641515.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACE

Gene Name

angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000024950

Encoded Proteins

IDBP-693956

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20937811

[Mus musculus] Ace and iNOS overexpression by myelomonocytic cells substantially boosts innate immunity and represents a new means to address serious bacterial infections such as L. monocytogenes and methicillin resistant S. Aureus.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159640:
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48447902-48467904

Strand

Forward strand

Band

Transcripts

ENSBTAT00000061106

ENSBTAP00000053314

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity

Biological Process

GO:0001822	kidney development
GO:0002446	neutrophil mediated immunity
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006508	proteolysis
GO:0007283	spermatogenesis
GO:0008217	regulation of blood pressure
GO:0042447	hormone catabolic process
GO:0060047	heart contraction