Version 5.4
Mus musculus Gene: Ace
Summary
InnateDB Gene IDBG-213293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ace
Gene Name angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms AW208573; CD143
Species Mus musculus
Ensembl Gene ENSMUSG00000020681
Encoded Proteins
IDBP-213295
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
IDBP-213297
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
IDBP-537478
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20937811
Ace and iNOS overexpression by myelomonocytic cells substantially boosts innate immunity and represents a new means to address serious bacterial infections such as L. monocytogenes and methicillin resistant S. Aureus.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159640:
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:105967945-105989964
Strand Forward strand
Band E1
Transcripts
ENSMUST00000001963 ENSMUSP00000001963
ENSMUST00000001964 ENSMUSP00000001964
ENSMUST00000132280 ENSMUSP00000119826
ENSMUST00000151657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0001822 kidney development
GO:0002446 neutrophil mediated immunity
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0008217 regulation of blood pressure
GO:0042447 hormone catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0060047 heart contraction
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159640
View Gene Order
ENSBTAG00000024950
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_196539
Metabolism of Angiotensinogen to Angiotensins pathway
KEGG
mmu04614
Renin-angiotensin system pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Cross-References
SwissProt P09470
TrEMBL
UniProt Splice Variant
Entrez Gene 11421
UniGene Mm.754
RefSeq NM_009598 NM_207624
OMIM
CCDS CCDS25544 CCDS25543
HPRD
IMGT
MGI ID MGI:87874
MGI Symbol Ace
EMBL BC040404 J03940 J04946 J04947 M55333 M61094
GenPept AAA37146 AAA37147 AAA37148 AAA37149 AAA37150 AAH40404
RNA Seq Atlas 11421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca