InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BCL2L1

Summary

InnateDB Gene

IDBG-641541.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L1

Gene Name

bcl-2-like protein 1

Synonyms

Bcl-xL; BCLX

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006526

Encoded Proteins

IDBP-693912

bcl-2-like protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24412611

[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171552:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:61766806-61817383

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008572

ENSBTAP00000008572

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.

Predicted by orthology
Total	87 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0000910	cytokinesis
GO:0001541	ovarian follicle development
GO:0001701	in utero embryonic development
GO:0001836	release of cytochrome c from mitochondria
GO:0007093	mitotic cell cycle checkpoint
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314	response to radiation
GO:0009566	fertilization
GO:0009615	response to virus
GO:0019050	suppression by virus of host apoptotic process
GO:0034097	response to cytokine
GO:0040007	growth
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0046898	response to cycloheximide
GO:0046902	regulation of mitochondrial membrane permeability
GO:0051402	neuron apoptotic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0060154	cellular process regulating host cell cycle in response to virus
GO:0070584	mitochondrion morphogenesis
GO:0071230	cellular response to amino acid stimulus
GO:0071312	cellular response to alkaloid
GO:0071480	cellular response to gamma radiation
GO:0071839	apoptotic process in bone marrow
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097284	hepatocyte apoptotic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000811	negative regulation of anoikis
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0097136	Bcl-2 family protein complex