InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PKP4

Summary

InnateDB Gene

IDBG-641595.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKP4

Gene Name

plakophilin-4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013773

Encoded Proteins

IDBP-693975

plakophilin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144283:
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila \'armadillo\' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:37815459-37929695

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000018330

ENSBTAP00000018330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0007043	cell-cell junction assembly
GO:0007155	cell adhesion
GO:0010628	positive regulation of gene expression
GO:0016337	single organismal cell-cell adhesion
GO:0032321	positive regulation of Rho GTPase activity
GO:0032467	positive regulation of cytokinesis

Cellular Component

GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009898	cytoplasmic side of plasma membrane
GO:0030057	desmosome
GO:0030496	midbody
GO:0044291	cell-cell contact zone
GO:0048471	perinuclear region of cytoplasm
GO:0051233	spindle midzone
GO:0072686	mitotic spindle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000144283

View Gene Order

ENSMUSG00000026991

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MJ11

UniProt Splice Variant

Entrez Gene

281406

UniGene

Bt.48203

RefSeq

NM_001191491

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02004476 DAAA02004477

GenPept

RNA Seq Atlas

281406