Version 5.4
Mus musculus Gene: Pkp4
Summary
InnateDB Gene IDBG-172382.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pkp4
Gene Name plakophilin 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026991
Encoded Proteins
IDBP-172384
plakophilin 4
IDBP-172386
plakophilin 4
IDBP-255706
plakophilin 4
IDBP-533410
plakophilin 4
IDBP-627120
plakophilin 4
IDBP-790265
plakophilin 4
IDBP-790266
plakophilin 4
IDBP-790267
plakophilin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144283:
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila \'armadillo\' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:59160850-59355208
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000102754 ENSMUSP00000099815
ENSMUST00000037903 ENSMUSP00000042249
ENSMUST00000112577 ENSMUSP00000108196
ENSMUST00000123908 ENSMUSP00000122152
ENSMUST00000122888
ENSMUST00000126749
ENSMUST00000124725
ENSMUST00000151452
ENSMUST00000124127
ENSMUST00000168631 ENSMUSP00000129836
ENSMUST00000183359 ENSMUSP00000139141
ENSMUST00000183625
ENSMUST00000184332 ENSMUSP00000139161
ENSMUST00000184705 ENSMUSP00000138895
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007043 cell-cell junction assembly
GO:0010628 positive regulation of gene expression
GO:0016337 single organismal cell-cell adhesion
GO:0032321 positive regulation of Rho GTPase activity
GO:0032467 positive regulation of cytokinesis
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009898 cytoplasmic side of plasma membrane
GO:0030057 desmosome
GO:0030496 midbody
GO:0044291 cell-cell contact zone
GO:0048471 perinuclear region of cytoplasm
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144283
View Gene Order
ENSBTAG00000013773
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2AS44 A2AS45 Q05D18
UniProt Splice Variant
Entrez Gene 227937
UniGene Mm.260938 Mm.392154 Mm.470140 Mm.486344
RefSeq NM_026361 NM_175464 XM_006499171 XM_006499172 XM_006499173 XM_006499175 XM_006499176 XM_006499177 XM_006499178 XM_006499179 XM_006499180
OMIM
CCDS CCDS16052 CCDS50588
HPRD
IMGT
MGI ID MGI:109281
MGI Symbol Pkp4
EMBL AL845536 BC019128 BX649232
GenPept AAH19128
RNA Seq Atlas 227937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca