InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NLRP12

Summary

InnateDB Gene

IDBG-641617.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP12

Gene Name

NACHT, LRR and PYD domains-containing protein 12

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000038149

Encoded Proteins

IDBP-694000

NLR family, pyrin domain containing 12

IDBP-694002

NLR family, pyrin domain containing 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17418609

[Homo sapiens] NLRP12 is a negative regulator of the NF-κB response in monocytes.

PMID 18280719

[Homo sapiens] NLRP12 negatively regulates non-canonical NF-κB pathway by inducing NIK degradation.

PMID 16203735

[Homo sapiens] NLRP12 is an antagonist of toll-like receptor-, tumour necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals.

PMID 25888258

[Mus musculus] Nlrp12 is an intrinsic negative regulator of T-cell-mediated immunity. Altered NF-kB regulation and Il4 production are key mediators of Nlrp12-associated disease.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142405:
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:61091348-61143063

Strand

Forward strand

Band

Transcripts

ENSBTAT00000066252	ENSBTAP00000055476
ENSBTAT00000057509	ENSBTAP00000051805

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0009968	negative regulation of signal transduction
GO:0031953	negative regulation of protein autophosphorylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0036336	dendritic cell migration
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045751	negative regulation of Toll signaling pathway
GO:0050710	negative regulation of cytokine secretion
GO:0050711	negative regulation of interleukin-1 secretion
GO:0050728	negative regulation of inflammatory response
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071345	cellular response to cytokine stimulus
GO:1901223	negative regulation of NIK/NF-kappaB signaling

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000142405

View Gene Order

ENSMUSG00000078817

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.101481 Bt.106406

RefSeq

NM_001192551

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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