Version 5.4
Homo sapiens Gene: NLRP12
Summary
InnateDB Gene IDBG-67727.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRP12
Gene Name NLR family, pyrin domain containing 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142405
Encoded Proteins
IDBP-67729
NLR family, pyrin domain containing 12
IDBP-67731
NLR family, pyrin domain containing 12
IDBP-247013
NLR family, pyrin domain containing 12
IDBP-247017
NLR family, pyrin domain containing 12
IDBP-247019
NLR family, pyrin domain containing 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17418609
NLRP12 is a negative regulator of the NF-κB response in monocytes.
PMID 18280719
NLRP12 negatively regulates non-canonical NF-κB pathway by inducing NIK degradation.
PMID 16203735
NLRP12 is an antagonist of toll-like receptor-, tumour necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals.
InnateDB Annotation from Orthologs
Summary
PMID 25888258
[Mus musculus] Nlrp12 is an intrinsic negative regulator of T-cell-mediated immunity. Altered NF-kB regulation and Il4 production are key mediators of Nlrp12-associated disease.
Entrez Gene
Summary This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:53793603-53824394
Strand Reverse strand
Band q13.42
Transcripts
ENST00000324134 ENSP00000319377
ENST00000345770 ENSP00000341428
ENST00000391775 ENSP00000375655
ENST00000391773 ENSP00000375653
ENST00000391772 ENSP00000375652
ENST00000492915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008588 release of cytoplasmic sequestered NF-kappaB
GO:0009968 negative regulation of signal transduction
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0036336 dendritic cell migration
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045381 regulation of interleukin-18 biosynthetic process
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0045751 negative regulation of Toll signaling pathway
GO:0050710 negative regulation of cytokine secretion
GO:0050711 negative regulation of interleukin-1 secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:1901223 negative regulation of NIK/NF-kappaB signaling
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078817
View Gene Order
ENSBTAG00000038149
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631573
RefSeq NM_001277126 NM_001277129 NM_144687
HUGO
OMIM
CCDS CCDS12864 CCDS62784 CCDS62785
HPRD 14803
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca