InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.50841

Summary

InnateDB Gene

IDBG-641652.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.50841

Gene Name

meiotic recombination protein DMC1/LIM15 homolog

Synonyms

DCM1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005936

Encoded Proteins

IDBP-694044

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100206:
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:110708930-110742207

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007794

ENSBTAP00000007794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0001556	oocyte maturation
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007276	gamete generation
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0009432	SOS response