InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: WDR19

Summary

InnateDB Gene

IDBG-641668.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR19

Gene Name

WD repeat-containing protein 19

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014512

Encoded Proteins

IDBP-694101

WD repeat domain 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157796:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:59993685-60065797

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019294

ENSBTAP00000019294

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662	coenzyme binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0007224	smoothened signaling pathway
GO:0015936	coenzyme A metabolic process
GO:0030326	embryonic limb morphogenesis
GO:0031076	embryonic camera-type eye development
GO:0035721	intraciliary retrograde transport
GO:0042384	cilium assembly
GO:0042471	ear morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0050877	neurological system process
GO:0055114	oxidation-reduction process
GO:0055123	digestive system development
GO:0060271	cilium morphogenesis
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061055	myotome development

Cellular Component

GO:0005929	cilium
GO:0030991	intraciliary transport particle A
GO:0031513	nonmotile primary cilium
GO:0031514	motile cilium
GO:0032391	photoreceptor connecting cilium

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000157796

View Gene Order

ENSMUSG00000037890

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228134

Signaling by Hedgehog pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_269412

Hedgehog 'off' state pathway

REACT_250064

Signaling by Hedgehog pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.43406

RefSeq

NM_001206027 XM_005207877

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas