Version 5.4
Mus musculus Gene: Wdr19
Summary
InnateDB Gene IDBG-166168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr19
Gene Name WD repeat domain 19
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037890
Encoded Proteins
IDBP-166170
WD repeat domain 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157796:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65199696-65260415
Strand Forward strand
Band C3.1
Transcripts
ENSMUST00000041892 ENSMUSP00000038098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0007224 smoothened signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0035721 intraciliary retrograde transport
GO:0042384 cilium assembly
GO:0042471 ear morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050877 neurological system process
GO:0055123 digestive system development
GO:0060271 cilium morphogenesis
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061055 myotome development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0030991 intraciliary transport particle A
GO:0031513 nonmotile primary cilium
GO:0031514 motile cilium
GO:0032391 photoreceptor connecting cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157796
View Gene Order
ENSBTAG00000014512
Not yet available
Pathways
NETPATH
REACTOME
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3UGF1
TrEMBL
UniProt Splice Variant
Entrez Gene 213081
UniGene
RefSeq NM_153391
OMIM
CCDS CCDS51509
HPRD
IMGT
MGI ID MGI:2443231
MGI Symbol Wdr19
EMBL AK052303 AK129413 AK147970 AY029258 BC046432
GenPept AAH46432 AAK38746 BAC34929 BAC98223 BAE28258
RNA Seq Atlas 213081

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca