InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBE2K

Summary

InnateDB Gene

IDBG-641762.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2K

Gene Name

Ubiquitin-conjugating enzyme E2 K

Synonyms

E2-25K; HIP2; HYPG; LIG

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020175

Encoded Proteins

IDBP-694160

Ubiquitin-conjugating enzyme E2 K

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078140:
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington\'s disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:60420296-60496136

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026871

ENSBTAP00000026871

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0034450	ubiquitin-ubiquitin ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0070936	protein K48-linked ubiquitination