Version 5.4
Homo sapiens Gene: UBE2K
Summary
InnateDB Gene IDBG-14649.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2K
Gene Name ubiquitin-conjugating enzyme E2K
Synonyms E2-25K; HIP2; HYPG; LIG; UBC1
Species Homo sapiens
Ensembl Gene ENSG00000078140
Encoded Proteins
IDBP-14651
ubiquitin-conjugating enzyme E2K
IDBP-365827
ubiquitin-conjugating enzyme E2K
IDBP-476604
ubiquitin-conjugating enzyme E2K
IDBP-484956
ubiquitin-conjugating enzyme E2K
IDBP-476479
ubiquitin-conjugating enzyme E2K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington\'s disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:39698044-39782792
Strand Forward strand
Band p14
Transcripts
ENST00000261427 ENSP00000261427
ENST00000445950 ENSP00000390483
ENST00000438068
ENST00000510934 ENSP00000425301
ENST00000513231
ENST00000503368 ENSP00000421203
ENST00000510719 ENSP00000421422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
Experimentally validated
Total 93 [view]
Protein-Protein 90 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008152 metabolic process
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029203
View Gene Order
ENSBTAG00000020175
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.50308 Hs.731985 Hs.732110 Hs.733130 Hs.735771
RefSeq NM_001111112 NM_001111113 NM_005339
HUGO
OMIM
CCDS CCDS33976 CCDS47043 CCDS47044
HPRD 04165
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca