InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BPIFA1

Summary

InnateDB Gene

IDBG-641779.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPIFA1

Gene Name

BPI fold-containing family A member 1

Synonyms

PLUNC; SPLUNC1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017098

Encoded Proteins

IDBP-694183

Protein Plunc

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21054862

[Homo sapiens] PLUNC is a protein able to inhibit Mycoplasma pneumoniae (Mp) growth and its production following Mp infection is regulated through Toll-like receptor 2 (TLR2) signalling, as determined in mice.

PMID 21787346

[Homo sapiens] PLUNC is a secretory protein that exhibits antimicrobial activity against Gram-negative bacteria and anti-inflammatory functions in respiratory infections.

PMID 21054862

[Mus musculus] Plunc is a protein able to inhibit Mycoplasma pneumoniae (Mp) growth and its production following Mp infection is regulated through Toll-like receptor 2 (TLR2) signalling.

PMID 21787346

[Mus musculus] Plunc is a secretory protein that exhibits antimicrobial activity against Gram-negative bacteria and anti-inflammatory functions in respiratory infections. (Demonstrated in human)

PMID 23470624

[Mus musculus] PLUNC1 is suppressed in pneumonic epithelium in the respiratory tract.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198183:
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:63247711-63254775

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022728

ENSBTAP00000022728

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008289	lipid binding

Biological Process

GO:0002376	immune system process
GO:0019731	antibacterial humoral response
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0050828	regulation of liquid surface tension
GO:0050891	multicellular organismal water homeostasis
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000198183

View Gene Order

ENSMUSG00000027483

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.11195

RefSeq

NM_174426 XM_005214492

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas