InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bpifa1

Summary

InnateDB Gene

IDBG-210271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bpifa1

Gene Name

BPI fold containing family A, member 1

Synonyms

LUNX; NASG; Plunc; SPLUNC1; SPURT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027483

Encoded Proteins

IDBP-210273

BPI fold containing family A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21054862

Plunc is a protein able to inhibit Mycoplasma pneumoniae (Mp) growth and its production following Mp infection is regulated through Toll-like receptor 2 (TLR2) signalling.

PMID 21787346

Plunc is a secretory protein that exhibits antimicrobial activity against Gram-negative bacteria and anti-inflammatory functions in respiratory infections. (Demonstrated in human)

PMID 23470624

PLUNC1 is suppressed in pneumonic epithelium in the respiratory tract.

InnateDB Annotation from Orthologs

Summary

PMID 21054862

[Homo sapiens] PLUNC is a protein able to inhibit Mycoplasma pneumoniae (Mp) growth and its production following Mp infection is regulated through Toll-like receptor 2 (TLR2) signalling, as determined in mice.

PMID 21787346

[Homo sapiens] PLUNC is a secretory protein that exhibits antimicrobial activity against Gram-negative bacteria and anti-inflammatory functions in respiratory infections.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198183:
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:154142880-154149219

Strand

Forward strand

Band

Transcripts

ENSMUST00000028985	ENSMUSP00000028985
ENSMUST00000144665
ENSMUST00000140006

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008289	lipid binding

Biological Process

GO:0019731	antibacterial humoral response
GO:0045087	innate immune response (InnateDB)
GO:0050828	regulation of liquid surface tension
GO:0050891	multicellular organismal water homeostasis
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005902	microvillus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000198183

View Gene Order

ENSBTAG00000017098

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.268852

RefSeq

NM_011126

OMIM

CCDS

CCDS16925

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas