InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.26676

Summary

InnateDB Gene

IDBG-641833.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.26676

Gene Name

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020173

Encoded Proteins

IDBP-694243

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20100929

[Homo sapiens] INPP5D (SHIP-1) is a critical negative regulator of IFN-beta production downstream of TLR3 through the regulation of TBK1 localization and activity.

PMID 20154203

[Homo sapiens] INPP5D is a negative regulator of GM-CSF-derived dendritic cell (DC) generation but a positive regulator of GM-CSF-derived DC maturation and function.

PMID 20385881

[Mus musculus] Inpp5d promotes while the Lyn/PI3K module negatively regulates activation in murine macrophages viaTlr2 and Tlr4 receptors.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168918:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5\' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:113403950-113541895

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026867

ENSBTAP00000026867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
GO:0051425	PTB domain binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0009968	negative regulation of signal transduction
GO:0016064	immunoglobulin mediated immune response
GO:0016311	dephosphorylation
GO:0030853	negative regulation of granulocyte differentiation
GO:0030889	negative regulation of B cell proliferation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045579	positive regulation of B cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045656	negative regulation of monocyte differentiation
GO:0045659	negative regulation of neutrophil differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045779	negative regulation of bone resorption
GO:0046856	phosphatidylinositol dephosphorylation
GO:0050777	negative regulation of immune response
GO:0050869	negative regulation of B cell activation