Version 5.4
Mus musculus Gene: Inpp5d
Summary
InnateDB Gene IDBG-178553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Inpp5d
Gene Name inositol polyphosphate-5-phosphatase D
Synonyms p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1; SIP-145
Species Mus musculus
Ensembl Gene ENSMUSG00000026288
Encoded Proteins
IDBP-178555
inositol polyphosphate-5-phosphatase D
IDBP-178557
inositol polyphosphate-5-phosphatase D
IDBP-627892
inositol polyphosphate-5-phosphatase D
IDBP-627894
inositol polyphosphate-5-phosphatase D
IDBP-627895
inositol polyphosphate-5-phosphatase D
IDBP-627896
inositol polyphosphate-5-phosphatase D
IDBP-627897
inositol polyphosphate-5-phosphatase D
IDBP-627898
inositol polyphosphate-5-phosphatase D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20385881
Inpp5d promotes while the Lyn/PI3K module negatively regulates activation in murine macrophages viaTlr2 and Tlr4 receptors.
InnateDB Annotation from Orthologs
Summary
PMID 20100929
[Homo sapiens] INPP5D (SHIP-1) is a critical negative regulator of IFN-beta production downstream of TLR3 through the regulation of TBK1 localization and activity.
PMID 20154203
[Homo sapiens] INPP5D is a negative regulator of GM-CSF-derived dendritic cell (DC) generation but a positive regulator of GM-CSF-derived DC maturation and function.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168918:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5\' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:87620312-87720507
Strand Forward strand
Band D
Transcripts
ENSMUST00000042275 ENSMUSP00000044647
ENSMUST00000072999 ENSMUSP00000072763
ENSMUST00000169754 ENSMUSP00000127941
ENSMUST00000163222
ENSMUST00000164592
ENSMUST00000168783 ENSMUSP00000131244
ENSMUST00000165554 ENSMUSP00000128700
ENSMUST00000163576 ENSMUSP00000130336
ENSMUST00000170300 ENSMUSP00000132384
ENSMUST00000167032 ENSMUSP00000126569
ENSMUST00000163548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0051425 PTB domain binding
Biological Process
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0008340 determination of adult lifespan
GO:0009968 negative regulation of signal transduction
GO:0016064 immunoglobulin mediated immune response
GO:0016311 dephosphorylation
GO:0030853 negative regulation of granulocyte differentiation
GO:0030889 negative regulation of B cell proliferation
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045659 negative regulation of neutrophil differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045779 negative regulation of bone resorption
GO:0046856 phosphatidylinositol dephosphorylation
GO:0050777 negative regulation of immune response
GO:0050869 negative regulation of B cell activation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168918
View Gene Order
ENSBTAG00000020173
Not yet available
Pathways
NETPATH
REACTOME
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_225145
Downstream TCR signaling pathway
REACT_199016
PI Metabolism pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_210793
Interleukin receptor SHC signaling pathway
REACT_261687
Signaling by Interleukins pathway
REACT_229531
Adaptive Immune System pathway
REACT_188643
Phospholipid metabolism pathway
REACT_225836
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
mmu04662
B cell receptor signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
REACTOME
REACT_12555
Downstream TCR signaling pathway
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_12526
TCR signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.15105
RefSeq NM_001110192 NM_001110193 NM_010566 XM_006529149 XM_006529150 XM_006529151 XM_006529153
OMIM
CCDS CCDS35655 CCDS48310 CCDS48311
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca