Version 5.4
Bos taurus Gene: POLG2
Summary
InnateDB Gene IDBG-641880.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLG2
Gene Name DNA polymerase subunit gamma-2, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018420
Encoded Proteins
IDBP-694289
DNA polymerase subunit gamma-2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000256525:
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49312498-49328600
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024509 ENSBTAP00000024509
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000020718
View Gene Order
ENSG00000256525
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q0VC30
TrEMBL
UniProt Splice Variant
Entrez Gene 505152
UniGene Bt.52381
RefSeq NM_001075191
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120380
GenPept AAI20381
RNA Seq Atlas 505152

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca