InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TBCD

Summary

InnateDB Gene

IDBG-641987.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBCD

Gene Name

Tubulin-specific chaperone D

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015414

Encoded Proteins

IDBP-694414

Tubulin-specific chaperone D

IDBP-694417

Tubulin-specific chaperone D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141556:
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:50388667-50536976

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000055015	ENSBTAP00000047992
ENSBTAT00000020484	ENSBTAP00000020484

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006457	protein folding
GO:0007023	post-chaperonin tubulin folding pathway
GO:0010812	negative regulation of cell-substrate adhesion
GO:0031115	negative regulation of microtubule polymerization
GO:0034333	adherens junction assembly
GO:0070830	tight junction assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction