Version 5.4
Bos taurus Protein: TBCD
Summary
InnateDB Protein IDBP-694417.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBCD
Protein Name Tubulin-specific chaperone D
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020484
InnateDB Gene IDBG-641987 (TBCD)
Protein Structure
UniProt Annotation
Function Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. {ECO:0000269PubMed:17704193, ECO:0000269PubMed:20740604}.
Subcellular Localization Cell junction, tight junction {ECO:0000269PubMed:17704193}. Lateral cell membrane {ECO:0000269PubMed:17704193}. Cytoplasm {ECO:0000269PubMed:17704193}. Cell junction, adherens junction {ECO:0000269PubMed:17704193}. Note=Localized in cell-cell contacts.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0005515 protein binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0006457 protein folding
GO:0007023 post-chaperonin tubulin folding pathway
GO:0010812 negative regulation of cell-substrate adhesion
GO:0031115 negative regulation of microtubule polymerization
GO:0034333 adherens junction assembly
GO:0070830 tight junction assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 tight junction
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
IPR022577 Tubulin-specific chaperone D, C-terminal
PFAM PF12612
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28205
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281515
UniGene Bt.3974
RefSeq NP_776619
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U61233
GenPept AAB17537

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca