InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.79081

Summary

InnateDB Gene

IDBG-642133.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.79081

Gene Name

kynureninase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032277

Encoded Proteins

IDBP-694558

Kynureninase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115919:
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Kynureninase is a pyridoxal-5\'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:53844155-53964125

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000045767

ENSBTAP00000043129

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016787	hydrolase activity
GO:0030170	pyridoxal phosphate binding
GO:0030429	kynureninase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0008152	metabolic process
GO:0009435	NAD biosynthetic process
GO:0019363	pyridine nucleotide biosynthetic process
GO:0019805	quinolinate biosynthetic process
GO:0034341	response to interferon-gamma
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034516	response to vitamin B6
GO:0043420	anthranilate metabolic process
GO:0097053	L-kynurenine catabolic process