InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KYNU

Summary

InnateDB Gene

IDBG-71532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KYNU

Gene Name

kynureninase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115919

Encoded Proteins

IDBP-71534

kynureninase

IDBP-71536

kynureninase

IDBP-294122

kynureninase

IDBP-294119

kynureninase

IDBP-386263

kynureninase

IDBP-812881

kynureninase

IDBP-812884

kynureninase

IDBP-812885

kynureninase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Kynureninase is a pyridoxal-5\'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:142877498-143055832

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000264170	ENSP00000264170
ENST00000375773	ENSP00000364928
ENST00000409512	ENSP00000386731
ENST00000410015	ENSP00000387296
ENST00000424385	ENSP00000401190
ENST00000460143
ENST00000621320	ENSP00000484801
ENST00000612147	ENSP00000481930
ENST00000613664	ENSP00000482009

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030170	pyridoxal phosphate binding
GO:0030429	kynureninase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0008152	metabolic process
GO:0009435	NAD biosynthetic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0019805	quinolinate biosynthetic process
GO:0034341	response to interferon-gamma
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034516	response to vitamin B6
GO:0034641	cellular nitrogen compound metabolic process
GO:0043420	anthranilate metabolic process
GO:0044281	small molecule metabolic process
GO:0097053	L-kynurenine catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026866

View Gene Order

ENSBTAG00000032277

Not yet available

Pathways

NETPATH

REACTOME

REACT_916

Tryptophan catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

B8ZZA3

UniProt Splice Variant

Entrez Gene

8942

UniGene

Hs.470126

RefSeq

NM_001032998 NM_001199241 NM_003937

HUGO

HGNC:6469

OMIM

605197

CCDS

CCDS2183 CCDS33299

HPRD

08940

IMGT

EMBL

AC013437 AC013444

GenPept

RNA Seq Atlas

8942