Version 5.4
Homo sapiens Gene: PCSK1N
Summary
InnateDB Gene IDBG-64216.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK1N
Gene Name proprotein convertase subtilisin/kexin type 1 inhibitor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102109
Encoded Proteins
IDBP-64218
proprotein convertase subtilisin/kexin type 1 inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48831094-48835633
Strand Reverse strand
Band p11.23
Transcripts
ENST00000218230 ENSP00000218230
ENST00000611033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 0
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
Biological Process
GO:0002021 response to dietary excess
GO:0007218 neuropeptide signaling pathway
GO:0009409 response to cold
GO:0010951 negative regulation of endopeptidase activity
GO:0016486 peptide hormone processing
Cellular Component
GO:0005615 extracellular space
GO:0005802 trans-Golgi network
GO:0030141 secretory granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039278
View Gene Order
ENSBTAG00000013250
Not yet available
Cross-References
SwissProt Q9UHG2
TrEMBL
UniProt Splice Variant
Entrez Gene 27344
UniGene
RefSeq NM_013271
HUGO HGNC:17301
OMIM 300399
CCDS CCDS14307
HPRD
IMGT
EMBL AF181562 BC002851
GenPept AAF22643 AAH02851
RNA Seq Atlas 27344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca