Version 5.4
Mus musculus Gene: Pcsk1n
Summary
InnateDB Gene IDBG-129784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcsk1n
Gene Name proprotein convertase subtilisin/kexin type 1 inhibitor
Synonyms AI848336; bLEN; KEP; lLEN; Pan3; PEN; PEN19; PEN20; proSAAS; SAAS; SAASCT
Species Mus musculus
Ensembl Gene ENSMUSG00000039278
Encoded Proteins
IDBP-129788
proprotein convertase subtilisin/kexin type 1 inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102109:
Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7919822-7924410
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000041096 ENSMUSP00000040342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0002021 response to dietary excess
GO:0007218 neuropeptide signaling pathway
GO:0009409 response to cold
GO:0010951 negative regulation of endopeptidase activity
GO:0016486 peptide hormone processing
Cellular Component
GO:0005615 extracellular space
GO:0005802 trans-Golgi network
GO:0030141 secretory granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102109
View Gene Order
ENSBTAG00000013250
Not yet available
Cross-References
SwissProt Q9QXV0
TrEMBL
UniProt Splice Variant
Entrez Gene 30052
UniGene Mm.4881
RefSeq NM_013892
OMIM
CCDS CCDS29979
HPRD
IMGT
MGI ID MGI:1353431
MGI Symbol Pcsk1n
EMBL AF181560 BC012263
GenPept AAF22641 AAH12263
RNA Seq Atlas 30052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca