InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CSRP3

Summary

InnateDB Gene

IDBG-642370.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSRP3

Gene Name

Cysteine and glycine-rich protein 3

Synonyms

CRP3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011869

Encoded Proteins

IDBP-694822

Cysteine and glycine-rich protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129170:
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5\' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:25994182-26014859

Strand

Forward strand

Band

Transcripts

ENSBTAT00000030320

ENSBTAP00000030304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008307	structural constituent of muscle
GO:0031433	telethonin binding
GO:0042805	actinin binding
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0003300	cardiac muscle hypertrophy
GO:0006874	cellular calcium ion homeostasis
GO:0007275	multicellular organismal development
GO:0007517	muscle organ development
GO:0030154	cell differentiation
GO:0033365	protein localization to organelle
GO:0035995	detection of muscle stretch
GO:0048738	cardiac muscle tissue development
GO:0055003	cardiac myofibril assembly
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030018	Z disc

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000129170

View Gene Order

ENSMUSG00000030470

View Gene Order

Cross-References

SwissProt

Q4U0T9

TrEMBL

UniProt Splice Variant

Entrez Gene

540407

UniGene

RefSeq

NM_001024689

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103108 DQ022067

GenPept

AAI03109 AAY45897

RNA Seq Atlas

540407