Version 5.4
Bos taurus Gene: BT.23261
Summary
InnateDB Gene IDBG-642662.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.23261
Gene Name serine/threonine-protein kinase 25
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009676
Encoded Proteins
IDBP-695139
serine/threonine-protein kinase 25
IDBP-695140
serine/threonine-protein kinase 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115694:
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:121065394-121074671
Strand Reverse strand
Band
Transcripts
ENSBTAT00000042598 ENSBTAP00000040234
ENSBTAT00000012764 ENSBTAP00000012764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007163 establishment or maintenance of cell polarity
GO:0023014 signal transduction by phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0051645 Golgi localization
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115694
View Gene Order
ENSMUSG00000026277
View Gene Order
Cross-References
SwissProt
TrEMBL G3X7P7
UniProt Splice Variant
Entrez Gene 373543
UniGene Bt.23261
RefSeq NM_183407
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009534
GenPept
RNA Seq Atlas 373543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca