InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CD97

Summary

InnateDB Gene

IDBG-642684.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD97

Gene Name

CD97 antigen precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021818

Encoded Proteins

IDBP-695177

CD97 antigen precursor

IDBP-695179

CD97 antigen precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21706400

[Homo sapiens] CD97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.

PMID 21706400

[Mus musculus] Cd97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123146:
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:12451153-12469054

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029084	ENSBTAP00000029084
ENSBTAT00000029086	ENSBTAP00000029086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding