Mus musculus Gene: Cd97
Summary
InnateDB Gene IDBG-172600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd97
Gene Name CD97 antigen
Synonyms AA409984; TM7LN1;
Species Mus musculus
Ensembl Gene ENSMUSG00000002885
Encoded Proteins
CD97 antigen
CD97 antigen
CD97 antigen
CD97 antigen
CD97 antigen
Protein Structure
InnateDB Annotation
Summary
Cd97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CD97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123146:
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:83723251-83741326
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000075843 ENSMUSP00000075240
ENSMUST00000002964 ENSMUSP00000002964
ENSMUST00000109802 ENSMUSP00000105427
ENSMUST00000139797
ENSMUST00000140606
ENSMUST00000154075
ENSMUST00000149368 ENSMUSP00000138393
ENSMUST00000166939 ENSMUSP00000128220
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Class B/2 (Secretin family receptors) pathway
GPCR ligand binding pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Z0M6
TrEMBL E9QJS7 E9QMJ5 Q9DC42 S4R1V8
UniProt Splice Variant
Entrez Gene 26364
UniGene Mm.334648
RefSeq NM_001163029 NM_001163030 NM_001163031 NM_011925 XM_006531033 XM_006531034 XM_006531035
OMIM
CCDS CCDS22461 CCDS52610 CCDS52611 CCDS52612
HPRD
IMGT
MGI ID MGI:1347095
MGI Symbol Cd97
EMBL AC164432 AF146344 AK004577 AK008101 BC006676 Y18365
GenPept AAF67800 AAH06676 BAB23386 BAB25461 CAB38246
ImmGen Cd97 (murine)
RNA Seq Atlas 26364