Mus musculus Gene: Cd97

Summary
InnateDB Gene IDBG-172600.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Cd97
Gene Name CD97 antigen
Synonyms AA409984; TM7LN1
Species Mus musculus
Ensembl Gene ENSMUSG00000002885
Encoded Proteins
IDBP-172602 CD97 antigen
IDBP-172604 CD97 antigen
IDBP-261603 CD97 antigen
IDBP-620916 CD97 antigen
InnateDB Annotation
Summary
PMID 21706400 Cd97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
InnateDB Annotation from Orthologs
Summary
PMID 21706400 [Homo sapiens] CD97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123146:
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8: 83723251-83741326
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000075843  ENSMUSP00000075240
ENSMUST00000002964  ENSMUSP00000002964
ENSMUST00000109802  ENSMUSP00000105427
ENSMUST00000139797 
ENSMUST00000140606 
ENSMUST00000154075 
ENSMUST00000149368 
ENSMUST00000166939  ENSMUSP00000128220
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral to membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000123146 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000021818 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_33090 Class B/2 (Secretin family receptors)
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18372 Class B/2 (Secretin family receptors)
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Z0M6 
TrEMBL E9QJS7 E9QMJ5 Q9DC42
UniProt Splice Variant
Entrez Gene 26364 
UniGene Mm.334648
RefSeq NM_001163029  NM_001163030  NM_001163031  NM_011925 
OMIM
CCDS CCDS22461  CCDS52610  CCDS52611  CCDS52612 
HPRD
IMGT
MGI ID MGI:1347095 
MGI Symbol Cd97
EMBL AC164432 AF146344 AK004577 AK008101 BC006676 Y18365
GenPept AAF67800  AAH06676  BAB23386  BAB25461  CAB38246 
ImmGen Cd97 (murine) 
RNA Seq Atlas 26364